Telomere-to-Telomere (T2T) Sequencing
Pioneering High-Quality Genome Assemblies for Biological and Applied Research
Complete, Gapless Genome Assemblies
High-quality, gapless genome assemblies are essential for advancing basic biology, medicine, and agriculture. Telomere-to-Telomere (T2T) sequencing resolves complex genomic regions, enabling researchers to unlock insights into genomic architecture, functional elements, and modifications that influence health, disease, and evolution.
With Nanopore sequencing, T2T sequencing becomes a reality through:
- Ultra-long reads for spanning repetitive regions.
- Pore-C sequencing for resolving chromosome conformation.
- Integrative data combining short reads (Q40+) to produce complete haplotype-resolved assemblies.
Advantages of Nanopore Long-Read Technology for T2T Sequencing
High-Quality, Gap-Free Assemblies
Resolve previously uncharted genomic regions.
Centromere Resolution
Detailed mapping of CentC-rich and CentC-poor centromeres.
Gene Clusters and Paralogs
Precise identification of paralogous gene clusters.
Transposable Elements & Duplications
Characterize transposable elements and segmental duplications with clarity.
Structural Variations and Complex Regions
Detect and resolve structural variations and highly repetitive genomic regions.
Telomere Biology & Aging
Investigate telomere dynamics and their implications in aging and longevity.
Disease Associations
Better resolution of genomic regions linked to health and disease.
Plant Molecular Breeding
Enhanced understanding of genetic markers and gene characterization for improved crop traits.
Applications of T2T Genomes
- Medical Genomics: Identify complex structural variants and their link to genetic disorders.
- Evolutionary Biology: Decode the intricate history of genomic evolution.
- Plant Genomics: Empower molecular breeding and genome-assisted trait selection.
- Aging Research: Study telomere integrity and its impact on cellular aging.
- Functional Genomics: Delve deeper into regulatory elements and their transcriptional impact.
Why Choose Genotypic for T2T Sequencing?
Expertise in Integrative Sequencing:
Proficiency in combining data from multiple platforms to deliver comprehensive genome assemblies.
Advanced Bioinformatics:
Custom pipelines for resolving complex genomic features.
Comprehensive Support:
From experimental design to computational analysis.
Proven Track Record:
Trusted by academia and industry for delivering high-quality genome assemblies.
Unlock the full potential of Telomere-to-Telomere sequencing with Genotypic Technology’s state-of-the-art solutions. Partner with us to decode the intricacies of genomes for transformative discoveries in biology and beyond.
